The brain scanner is a piece of philosophical fiction made fact. It was among the most common creations of thought experiments, along with the brain-vat and the mindless robot. With the imaginary scanner, readings were taken of each other's brain activity, thereby learning everything about other minds, or very little, depending on the outcome of the thought experiment. The scanners that are now in use—those that allow us to do functional magnetic resonance imaging (fMRI), for example—are a little different to (...) those imagined, perhaps, but they have very much arrived. They are in daily use in hundreds of laboratories, and for the past 15 years or so have been grabbing headlines the world over with breakthrough .. (shrink)

© 2015, Springer-Verlag Berlin Heidelberg.Genetic studies have identified single nucleotide polymorphisms associated with the risk of prostate cancer. It remains unclear whether such genetic variants are associated with disease aggressiveness. The NCI-SPORE Genetics Working Group retrospectively collected clinicopathologic information and genotype data for 36 SNPs which at the time had been validated to be associated with PC risk from 25,674 cases with PC. Cases were grouped according to race, Gleason score and aggressiveness. Statistical analyses were used to compare the frequency (...) of the SNPs between different disease cohorts. After adjusting for multiple testing, only PC-risk SNP rs2735839 was significantly and inversely associated with aggressive and high-grade disease in European men. Similar associations with aggressive and high-grade disease were documented in African-American subjects. The G allele of rs2735839 was associated with disease aggressiveness even at low PSA levels in both European and African-American men. Our results provide further support that a PC-risk SNP rs2735839 near the KLK3 gene on chromosome 19q13 may be associated with aggressive and high-grade PC. Future prospectively designed, case-case GWAS are needed to identify additional SNPs associated with PC aggressiveness. (shrink)

In the late 1720s, Daniel Turner and James Blondel engaged in a pamphlet dispute over the power of the maternal imagination. Turner accepted the long-standing belief that a pregnant woman's imagination could be transferred to her unborn child, imprinting the foetus with various marks and deformities. Blondel sought to refute this view on rational and anatomical grounds. Two issues repeatedly received these authors' attention: the identity of imagination, and its power in pregnant women; and the process of generation and foetal (...) development. In their discussions of these issues, differences between the authors' acceptance of general medical theories and philosophies became apparent. Blondel invoked Newtonian matter theory, experimental philosophy, and iatro-mechanism, while Turner adhered more to the authority of the Ancients and advocated a more direct role for the Creator as an alternative to mechanism in explaining natural phenomena. Additionally, the authors held differing views of what they regarded as experience. The widespread contemporary interest in their dispute suggests that Turner and Blondel raised the phenomenon of the maternal imagination from an issue of folk belief to a concern of eighteenth-century medicine. (shrink)

This article examines the emerging pattern of 19th-century warfare against the backdrop of Modernity’s expressed optimism regarding social and economic progress. The author argues that in the modern period western countries have been insufficiently conscious of the consequences of weapons of mass destruction and of their own involvement in acts of mass violence. The article identifies a modernist culture radically different from that articulated by Enlightenment narratives.

In this essay, we discuss how Descartes arrives at his mature view of material causation. Descartes’ position changes over time in some very radical ways. The last section spells out his final position as to how causation works in the world of material objects. When considering Descartes’ causal theories, it is useful to distinguish between ‘vertical’ and ‘horizontal’ causation. The vertical perspective addresses God’s relation to creation. God is essential being, and every being other than God depends upon God in (...) order to exist and to continue in existence.Thus, from the vertical perspective, the act of creating and fact of coming into existence are co-extensive notions. This metaphysical/theological framework is the basis of Descartes’ commitment to three interrelated notions: that genuine causes and effects occur simultaneously; that causing is appropriately the case only when the cause is acting; and the view that God is the efficient, total, and continuous cause of everything that exists and every action that occurs. So from the vertical perspective, things are nothing without God’s continuous creation, and there is a problem in articulating how they are said to have independent being and causal efficacy. It is in terms of these commitments that Descartes’ views on horizontal, or material, causation must be approached. We will make apparent the radical extent to which his account of intra-worldly causation abandons his earlier and more traditional views about material causation. To this end we discuss Descartes’ journey to his mature position by emphasizing the growing epistemic limitations of his philosophy, which culminate in what we call his epistemic stance. (shrink)

In this article, three descriptive models are described and compared in an attempt to discover the minimum number of concepts and relations necessary to an abstract description of social structure. It is argued that a "situational model" which uses the concepts of social time, social space and social role together with the relations of internal structure and external distribution is both adequate to the task and superior to the two other models. The advantages and implications of the situational model are (...) discussed. (shrink)

Tuberculosis was clearly one of the most predominant diseases of the early twentieth century. At this time, Americans involved in the eugenics movement grew increasingly interested in methods to prevent this disease's potential hereditary spread. To do so, as this essay examines, eugenicists' attempted to shift the accepted view that tuberculosis arose from infection and contagion to a view of its heritable nature. The methods that they employed to better understand the propagation and control of tuberculosis are also discussed. Finally, (...) the essay explores the interpretative analyses of data that the Eugenics Record Office used in an attempt to convince contemporaries of the hereditary transmission of tuberculosis. (shrink)